Hormones

My mother, her cousin and her uncle were having this discussion:

Mother: Yeah my leg is very bad. The doctor says I could need a surgery.
Cousin: Don't get a surgery. The success rate isn't that great. Uncle took all sorts of medicines and now he's fine.
Mother: Uncle, what injury did you have?
Uncle: Osteopeorosis. They treated it with some herbal ayurvedic medicines and now its fine.
Cousin: Yes. But uncle has always been so fit and this injury was so sudden it was strange.
Mother: Must be hormonal.
Rusty: "Men don't have hormonal changes when they're old ........"
Mother: Maybe uncle's not a man.
Uncle: ????